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The Reading Chronicle's Paul Carey tweeted the news.
Anton Ferdinand is unavailable for Saturday after picking up an injury in training. Jamie Mackie also out. #readingfc
— Paul Carey (@PaulCareySport) January 22, 2015
The news comes as yet another blow for Ferdinand who's managed around 50 minutes of first team football since joining on a free transfer this summer.
Mackie meanwhile has also endured his own fair share of injury problems, with Carey reporting that he'll miss out on Saturday's game due to a groin injury.
Elsewhere and Steve Clarke should have a fully fit squad to choose from, aside from Craig Tanner who left on a loan deal earlier today.
So who makes your XI for this weekend's FA Cup clash? Feel free to pick your team here using our squad selector.