It has been a terrible start to the season for Rotherham, with The Millers lying rock bottom of the league with six points from their first 13 games and are six points from safety.
This tweet sums up Rotherham's form this season.
This has led to the sacking of former Hibernian manager Alan Stubbs, with former Wolves manager Kenny Jacket replacing him with immediate effect.
Danny Ward vs Liam Moore
Signed from fellow Championship side Huddersfield in January 2015, the 25 year old is The Millers' main man up front.
Last season, Ward got four goals in 34 appearances, this campaign however, Ward has already beaten that with six goals in 13 appearances this season.
Looking to limit Ward's opportunities in front of goal will be Liam Moore. The central defender has looked shaky in recent games and will need to be back on form if Reading are to come away with three points.
The aerial battle between Ward and Moore should be a terrific watch, with both players being over 6 foot tall and both looking to make a point to their respected managers.
Here's a video of Ward demonstrating his ability to finish when left in space, with the striker scoring the winner in Rotherham's 2-1 win over Brentford last season.
Jon Taylor vs Tyler Blackett
The 24 year old Liverpudlian who was signed from League 1 side Peterborough is one of Rotherham's best players.
Operating on either wing, Taylor has done well in the circumstances scoring three goals in 13 appearances, including two against Nottingham Forest.
It will likely be Tyler Blackett's job to stop Taylor from getting the ball into the box and supplying Rotherham's strikers with something to feed on.
Blackett has been criticised recently, with the left back being substituted in each of the last two games. This means that Blackett will have to perform much better if he is to keep his place.
It is worth noting that Chris Gunter may also be called to deal with Taylor, with the Welshman being criticised by the Reading fans for his recent performances and being at fault for Aston Villa's first goal in their 2-1 win at the Madjeski Stadium.
If the full backs can contain Taylor, then this should hopefully tip the balance in Reading's favour.
Stephen Kelly vs Roy Beerens
The former Republic of Ireland international has played nine games so far The Millers this season, captaining his side in five of those games.
The game against The Royals will be an interesting one, with Kelly coming up against his former side where he made 52 appearances between January 2013 and July 2015.
Looking to give Kelly a hard time will be Roy Beerens. The Dutchman has made a decent start to his career scoring two goals in all competitions so far this season. However Beerens has come in for criticism with some Reading fans saying "he lacks a final product".
From what I've seen this statement is justified, but Beerens is one of those players who produce something out of nothing, whether this is a trick or something that gets the Reading fans out of their seats.
If Beerens can get his final ball up to scratch then this will be a huge benefit to the team, as this should hopefully give the supply that striker Yann Kermorgant is craving for.
However Beerens will have his work cut against a Rotherham side that is surely going to step up with their new manager Kenny Jackett now at the helm.