Will Grigg vs Liam Moore
The Northern Irishman is a real fans' favourite with the Wigan supporters, having fired the Latics to the League One title and promotion last season.
During that campaign Grigg scored 25 goals in 40 league appearances, earning the striker a call up to the European Championships last summer.
He also earned the famous "Will Grigg's on fire" chant, which reached the top ten in the UK singles chart.
Looking to put a dampener on Grigg will be Liam Moore; the centre back has helped his side earn two consecutive clean sheets for the Royals in the last two games, taking six points.
It will be down to Moore to stop Grigg from finding space in the box and getting shots away on Ali Al-Habsi's goal.
Grigg may have only scored five goals in 15 appearances this season, but his is very capable of finding the net when it matters, as this video demonstrates.
Jordi Gomez vs Joey van den Berg
The 31 year old delighted the Wigan faithful in the summer after signing a one year contract to return to the club he left at the end of the 2013/14 season.
Gomez is one of Wigan's main source of goals from midfield having scored two goals in eight appearances this season. Playing in the number 10 role behind the striker, the Spaniard is the main link between midfield and attack and will need to be kept an eye on.
Looking to give Gomez a hard time will be Joey van den Berg. The Dutchman has been fantastic so far this season with his tackling and work rate, but the midfielder is one booking away from suspension.
Van den Berg is also known for being very physical and will need to use this against a player that has scored four goals in five appearances against The Royals, including a hat-trick when the teams met during the 2012/13 season at the DW Stadium.
If Van den Berg can contain Gomez this should put the Royals in good stead as they look to beat Wigan for the first team since the 2007/08 season.
Jake Buxton vs Yann Kermorgant
Signed from Derby in the summer, Buxton is one of the main men in the Wigan back line.
During the 12 games that he's played, Wigan have only kept three clean sheets and conceded 11 goals.
Looking to cause Buxton problems throughout the game will be Yann Kermorgant. The Frenchman is lacking confidence having not scored from open play since he scored the winner against Cardiff back in August.
Kermorgant should fancy his chances against a Wigan defence that has conceded 17 goals so far this season. However, he will have it all to do against a centre back looking to make a statement to his new manager Warren Joyce.