Representing the duo's first meeting since 2012 when Reading drew 2-2 with Palace en route to promotion, a certain Glenn Murray scoring a late equaliser, the Royals will look to claim their first win over the Eagles since 2010. Of course, Alan Pardew will return to the Madejski Stadium as Palace boss.
Due to be played on the weekend of March 11-14, the tie will be moved to the tastes of the television executives as all quarter-final matches will be televised.
Goals from Paul McShane, Michael Hector, and Lucas Piazon sent Reading into their fourth quarter-final in seven years and the Royals will look to improve on their record of this particular occasion under McDermott. Previous appearances under the ex-Slough boss saw a two-goal lead squandered in defeat at home to Aston Villa while Manchester City dispatched Reading 1-0 in 2011.
Are you happy with the tie? What are Reading's chances of a second-successive semi-final appearance? Comment below.