Jake Cooper vs David Goodwillie
The Scottish striker, who had a spell at Blackburn when they were in the Premier League, is likely to start on Tuesday night against Jake Cooper. Cooper is likely to be given the nod having been unused substitute in the 1-0 win over Preston on Saturday.
Goodwillie is looking to rebuild his career in English football, having signed from Scottish Premiership side Aberdeen in the summer.
With his height and strength, Goodwillie will be the striker up top that Plymouth will look for in order to win headers and hold the ball up, allowing his teammates to join the attack.
This is likely to be fascinating battle between the two players, with Cooper being 6 ft 4 in and Goodwillie being 5 ft 9 in.
Whoever wins this battle will go a long way as to which team comes out on top.
George Evans vs Graham Carey
The former Republic of Ireland under 21 international is likely to start on Tuesday night and is arguably one of Plymouth's best players. Last season he got 12 goals and 16 assists in 46 games for the Pilgrims.
He will be up against George Evans, who is likely to keep his place following his impressive performance on Saturday.
Evans who played in the holding role against Preston, will be looking to stop Carey making any impact on the game and from linking up with the two strikers that Plymouth play in Goodwillie and Jimmy Spencer.
If Evans can do this then this will be a huge gain for Reading, as they'll be stopping Plymouth's main man in midfield from replicating his form from last season.
Yakou Meite vs Sonny Bradley
Having been an unused substitute in the win over Preston, Yakou Meite will be looking to make his first ever start in English football and his debut for Reading. Meite, (from videos on YouTube) looks a very exciting player, with pace, trickery and the ability to pull something from out of the bag. This could therefore be a very good opportunity for Meite to get experience of playing in English football for the first time and show what he can do.
Looking to stop him from making an instant impact, will be Plymouth centre back Sonny Bradley. Bradley is a new signing at Home Park, having signed on a free transfer from Crawley Town in the summer.
Bradley kept 11 clean sheets for Crawley last season and will be hoping he can keep another one on Tuesday night.
This will be a fascinating battle between Meite and Bradley, mainly due to their height. Meite is 6 ft and 1/2 in tall, while Bradley is 6 ft and 4 in tall. So it will be interesting, as to who wins the headers from the long balls and crosses.