Elvis Manu vs Liam Moore
The Ghanaian striker who was born in Holland has started every round so far this season and is expected to feature again on Tuesday night, with Brighton manager Chris Hughton expecting to make changes from his side's 1-0 win at Burton Albion on Saturday.
Manu has scored in every round so far in the EFL cup, with goals against Colchester and Oxford and will therefore be hoping to repeat his goal-scoring heroics for the Seagulls against the Royals on Tuesday.
Looking to keep him quiet will be Liam Moore, the centre-back performed incredibly against Barnsley on Saturday helping his side to three points despite being down to ten men for nearly an hour. He and the back five that played on Saturday have rightfully earned their spot in the starting line-up.
It will be interesting therefore as to how Moore deals with Manu, who is a relative unknown in English football.
Oliver Norwood vs George Evans
The former Reading midfielder who left the Royals in the summer is expected to start against his former employees for the first time.
Since joining Brighton, Norwood has appeared eight times for his new club, but has yet to score so what's the betting he comes with a 25 yard screamer on Tuesday night?
Looking to make sure this does not happen will be George Evans. The midfielder has, for me, been fantastic since coming into the side to replace Joey van den Berg and is bound to keep his place following his recent performances.
Evans will be looking to make sure that Norwood does not impact the game whatsoever. This will mean Evans will have to stop Norwood's intricate delivery up to the front three that Brighton play and more importantly stop the Northern Irishman from getting a shot away, as Reading fans know all too well.
If Evans can do this, then Reading will have a good chance of coming away with a win on the South Coast.
Uwe Hünemeier v Joseph Mendes
The German centre-half who was signed from Bundesliga 3 side SC Paderborn in the summer of 2015, has made only two appearances for Birghton this season, in the EFL Cup and in the controversial EFL Trophy.
Hünemeier is set to be up against Joseph Mendes, the striker who will be looking to get on the score-sheet and give manager Jaap Stam something to think about. Stam is likely to deploy Mendes as the lone striker up front, which will mean he will need to hold the ball up in order to give his teammates a chance to get forward and spearhead attacks.
The battle is also gong to be a keen and physical one with both players being over 6 foot tall, in a game that could last for up to 120 minutes. It will therefore be interesting as to who comes out on top, by winning the headers from the long balls and crosses for his respective team.