Nahki Wells vs Liam Moore
Nahki Wells is Huddersfield's main man up front and is a forward that is feared by many Reading fans. This is because in the nine games that Wells has played against Reading, he has scored five goals, with most of them coming at the John Smith's stadium. So what's the betting that he finds the net against Reading again?
Last season the Bermudan striker scored 17 goals in 44 appearances in the Championship as Huddersfield finished 19th, comfortably clear of the relegation zone. However this season, Wells has scored nine goals in 30 league appearances - this may not seem a lot but his goals have been vital in getting Huddersfield to where they are in the league.
Looking to make sure Wells does not keep up his habit of scoring against Reading will be Liam Moore. The centre-back has been a revelation since joining from Leicester in the summer and is surely in line to be one of main contenders for player of the season.
Moore will have to be at his best to deal with Wells, with the striker having pace, trickery and the ability to finish when left in space.
If Moore can contain the 26 year old and stop him from getting shots away, then this will be a big plus for Reading as they will be nullifying one of Huddersfield's main threats.
Danny Williams vs Aaron Mooy
Australian Aaron Mooy is currently on loan at the Terriers having signed from Manchester City in the summer. The midfielder is Huddersfield's main source of creativity in the middle in the park, shown by the fact that he has six assists in 33 appearances in all competitions, as well as getting on the scoresheet twice himself.
Mooy has been one of the best players in this talented Huddersfield side with his passing and his vision, meaning that he'll need to be a closely marked man when the sides meet.
Looking to stop the 26 year old from pulling the strings in midfield will be Danny Williams. The American has had a much improved season so far with his power, pace and drive from midfield. He has also scored vital goals when it matters, such as the equaliser against Brentford last time out which sent the Royals on their way in claiming a vital win.
Williams will have to close the space down and stop Mooy from getting time on the ball. If the Terriers' playmaker gets time, he is very capable of creating a defence-splitting pass that Nahki Wells and his strike partner Izzy Brown will look to thrive on. But if Williams can disrupt the 26 year old, then it should give Reading a huge boost in coming away with a good result.
Michael Hefele vs Lewis Grabban
Hefele signed from German side Dynamo Dresden in the summer and has nailed himself down as one of the first names on manager David Wagner's team-sheet.
Playing in the heart of the Huddersfield defence, the 26 year old has kept six clean sheets in the 24 games he played in. However, the centre back has also only conceded 20 goals in those games.
Hefele also grabbed the headlines a few weeks ago when he got the winner against Leeds, sparking wild scenes amongst the Huddersfield fans.
Looking to get a sniff at the Terriers goal will be Lewis Grabban. The striker is likely to start on Tuesday night with Jaap Stam looking to use the same tactics that got him the win against Brentford, due to the high pressing game that Huddersfield play.
In the past Grabban has been known for scoring when it counts, meaning it'll be down to the forward to get the goals in this massive game for both sides. However he'll be up against a tough Huddersfield defence that concedes very few goals especially at home.
Here's Hefele scoring the winner in Huddersfield's 2-1 win over Leeds.