Chris Gunter vs Helder Costa
The Portuguese man who initially signed on loan from his native side Benfica in the summer, is arguably Wolves' best player and one of the best in the Championship.
So far this season Costa has scored ten goals in 34 appearances in all competitions, including one in his sides win at Stoke in the third round of the FA Cup.
Out of the ten goals scored, eight of them have been scored in the league. That's the same amount as Yann Kermorgant and one less than Fulham striker Chris Martin.
Performances such as the one against Liverpool in the FA Cup fourth round, persuaded the Wolves board to make Costa's stay a permanent one, with the club spending a club record £13 million to secure his services.
Costa also has nine assists in all competitions along with his goals, meaning that he will need be a marked man when Wolves visit the Madjeski.
Looking to keep talented winger quiet will be Chris Gunter, the right back has struggled in recent weeks firstly against Huddersfield and then against Brighton last time out.
Gunter has played poorly against talented wingers throughout the whole of this season and he'll be up against a another brilliant young midfielder.
The right back therefore has to stop standing off his man and contain him, furthermore Gunter must also stop the crosses from coming into the box, which is another area that Gunter has struggled in.
If the Welshman can stop one of the best young players in the Championship, then it should provide the confidence for his side to kick on and win the three points.
Here's a video demonstrating just how good Costa is.
Danny Williams vs Dave Edwards
The 31-year-old plays in the heart of the midfield three that his side like to play.
So far this season Edwards has found the back of the net nine times in 30 Championship appearances and the attacking midfielder also has three assists to his name.
The Welshman will be looking to spearhead attacks for his team with his passing and vision, something that can cause any defence problems.
It will therefore be Danny Williams' job to stop Edwards from dictating the play and supplying wingers Helder Costa and Andreas Weimann, along with striker Jon Dadi Bodvarrsson, with chances to create and score.
Williams is known for his ability to break play up through his physical approach and will be hoping to use this to full effect when the sides meet.
If the American can do this then this will be a huge plus for Reading, as they'll be stopping Wolves' main man in midfield from inflicting any damage to this Reading side.
Yann Kermorgant vs Daniel Batth
The centre back is the captain of the Wanderers and has appeared in all, but two Championship games.
Batth is one of the current longest serving members of the Wolves team having made 182 appearances for the Championship club since his move from Sheffield Wednesday back in 2011.
The defender is one Wolves best players with his no nonsense defending and passion for the Wanderers shirt.
However the centre half has endured a tough season with his side conceding 36 goals so far this season and has only kept seven clean sheets.
It is why that despite the quality that Wolves posses the Midland club are in 20th place, two points above the relegation zone.
Centre forward Yann Kermorgant will looking to take advantage of a leaky Wolves defence, the Frenchman is the Royals joint top goal-scorer with eight goals.
However in the last two games Kermorgant has lacked the service that is required from him to have an impact.
The game against Bristol City away demonstrated that with the right service, the striker can be lethal with his finishing.
This is something that the Royals will need to utilise, if they are come away with three points and get their promotion push back on track.